The best time to take magnesium supplements can vary based on individual preferences and needs. However, here are a few general guidelines that might help. With Meals Taking magnesium supplements with meals is a common recommendation. This can help reduce the potential for stomach upset, as magnesium can sometimes have a laxative effect on an empty stomach. Taking magnesium with food can also aid in its absorption. Split Doses If you need to take a larger dose of magnesium, consider splitting it into smaller doses throughout the day. This can help improve absorption and reduce the risk of gastrointestinal discomfort. Evening or Before Bed Some people find that taking magnesium supplements in the evening or before bed is beneficial. Magnesium can have a relaxing effect and might help promote better sleep. It can also potentially help with muscle relaxation, which could be useful if you have issues like restless legs or muscle cramps.